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His or HIS may refer to:
- Hangzhou International School
- a gender-specific pronoun, the possessive form of he
- His, Haute-Garonne, a commune in the Haute-Garonne département, in France
- Hightech Information System Limited, a HK graphics card company
- Hospital information system, an enterprise resource planning system that caters to hospital needs
- Honeywell Information Systems, the former computer division of Honeywell
- Histidine, an amino acid
- Wilhelm His, Sr., a cell theorist
- Wilhelm His, Jr., an anatomist
- Microsoft Host Integration Server, a technology to connect a Microsoft Windows platform with a non-Microsoft platform such as IBM mainframes.
- a school, Harare International School
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