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Sham may refer to:
- Sham (horse), American Thoroughbred horse born in 1970 who won multiple graded stakes races.
- Sham, Alpha Sagittae star.
- Sham, (Arabic: شام), al-Sham, or Bilad al-Sham, endonym of the region bordering the eastern Mediterranean Sea, usually known as the Levant or Greater Syria, comprised of Syria, Lebanon, Palestine, Jordan and Israel.
- Ash-Shām or Sham (الشام) sometimes refers simply to Damascus, the largest city in the region.
- Sham (One Piece), a minor character in the Eiichirō Oda's manga One Piece
- Sham 69, English punk band
- Sham, a word for the cover of a pillow
- Sham operated group, a control group in laboratory experiments involving surgical procedures.
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